In this article I review mechanisms that underpin epigenetic inheritance of CpG methylation
and histone H3 lysine 9 methylation (H3K9me) in chromatin in fungi and mammals. CpG …

Significant effort has been spent attempting to unravel the causal relationship between
histone post-translational modifications and fundamental DNA processes, including …

In the process of DNA replication, the first steps in restoring the chromatin landscape involve
parental histone recycling and new histone deposition. Disrupting histone recycling to either …

We present replication-aware single-molecule accessibility map** (RASAM), a method to
nondestructively measure replication status and protein-DNA interactions on chromatin …

The FLO genes in Saccharomyces cerevisiae are repressed by heterochromatin formation,
involving histone deacetylases, transcription factors and non-coding RNAs. Here, we report …

DNA replication, a fundamental process in all living organisms, proceeds with continuous
synthesis of the leading strand by DNA polymerase ε (Pol ε) and discontinuous synthesis of …

Heterochromatin plays a critical role in regulating gene expression and maintaining genome
integrity. While structural and enzymatic components have been linked to heterochromatin …

Highlights•Elongating transcription and replication machineries mediate the recycling of
nucleosomes behind them.•RNAPII can be recycled to nascent strands upon replication fork …

Simple Summary MCM2-7, evolutionarily conserved and essential for DNA replication,
functions as the central factor for the eukaryotic replicative DNA helicase. Here, we …

Establishing, maintaining, and removing histone post-translational modifications associated
with heterochromatin is critical for sha** genomic structure and function as a cell …