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Association of glycemic indices (hyperglycemia, glucose variability, and hypoglycemia) with oxidative stress and diabetic complications
E Papachristoforou, V Lambadiari… - Journal of diabetes …, 2020 - Wiley Online Library
Oxidative stress (OS) is defined as a disturbance in the prooxidant‐antioxidant balance of
the cell, in favor of the former, which results in the antioxidant capacity of the cell to be …
the cell, in favor of the former, which results in the antioxidant capacity of the cell to be …
Targeting endothelial dysfunction and inflammation
Vascular endothelium maintains vascular homeostasis through liberating a spectrum of
vasoactive molecules, both protective and harmful regulators of vascular tone, structural …
vasoactive molecules, both protective and harmful regulators of vascular tone, structural …
Endothelial functions
S Godo, H Shimokawa - Arteriosclerosis, thrombosis, and vascular …, 2017 - ahajournals.org
The endothelium plays important roles in modulating vascular tone by synthesizing and
releasing a variety of endothelium-derived relaxing factors, including vasodilator …
releasing a variety of endothelium-derived relaxing factors, including vasodilator …
Metformin: from mechanisms of action to therapies
Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …
Mouse models of atherosclerosis: a historical perspective and recent advances
Atherosclerosis represents a significant cause of morbidity and mortality in both the
developed and develo** countries. Animal models of atherosclerosis have served as …
developed and develo** countries. Animal models of atherosclerosis have served as …
Endothelial cell metabolism in atherosclerosis
Atherosclerosis and its sequelae, such as myocardial infarction and stroke, are the leading
cause of death worldwide. Vascular endothelial cells (EC) play a critical role in vascular …
cause of death worldwide. Vascular endothelial cells (EC) play a critical role in vascular …
Protective effects of metformin in various cardiovascular diseases: clinical evidence and AMPK‐dependent mechanisms
Y Bu, M Peng, X Tang, X Xu, Y Wu… - Journal of Cellular …, 2022 - Wiley Online Library
Metformin, a well‐known AMPK agonist, has been widely used as the first‐line drug for
treating type 2 diabetes. There had been a significant concern regarding the use of …
treating type 2 diabetes. There had been a significant concern regarding the use of …
Unveiling the role of inflammation and oxidative stress on age‐related cardiovascular diseases
AJPO de Almeida… - Oxidative medicine …, 2020 - Wiley Online Library
The global population above 60 years has been growing exponentially in the last decades,
which is accompanied by an increase in the prevalence of age‐related chronic diseases …
which is accompanied by an increase in the prevalence of age‐related chronic diseases …
Targeting endoplasmic reticulum stress in insulin resistance
The endoplasmic reticulum (ER) is involved in the development of insulin resistance and
progression to type 2 diabetes mellitus (T2DM). Disruption of ER homeostasis leads to ER …
progression to type 2 diabetes mellitus (T2DM). Disruption of ER homeostasis leads to ER …
Pharmacological basis and new insights of resveratrol action in the cardiovascular system
Resveratrol (trans‐3, 4′, 5‐trihydroxystilbene) belongs to the family of natural phytoalexins.
Resveratrol first came to our attention in 1992, following reports of the cardioprotective …
Resveratrol first came to our attention in 1992, following reports of the cardioprotective …