The incidence of Alzheimer's disease (AD) is growing every day and finding an effective
treatment is becoming more vital. Amyloid-β (Aβ) has been the focus of research for several …

Emodin is an anthraquinone derivative found in the roots and bark of a variety of plants,
molds, and lichens. Emodin has been used as a traditional medication for more than 2000 …

Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …

Importance Sleep and circadian problems are very common in Alzheimer disease (AD).
Recent animal studies suggest a bidirectional relationship between sleep and β-amyloid …

Aggregation of β-amyloid (Aβ) in the brain begins to occur years before the clinical onset of
Alzheimer's disease (AD). Before Aβ aggregation, concentrations of extracellular soluble Aβ …

The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …

Clinicopathological evidence suggests that the pathology of Alzheimer's disease (AD)
begins many years before the appearance of cognitive symptoms. Biomarkers are required …

Aβ Immunotherapy is a promising therapeutic approach for Alzheimer's disease. Preclinical
studies demonstrate that plaque prevention is possible; however, the more relevant …

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by the
accumulation of extracellular plaques and intracellular tangles. Recent studies support the …

Lymphatic vasculature drains interstitial fluids, which contain the tissue's waste products,
and ensures immune surveillance of the tissues, allowing immune cell recirculation. Until …