Antisense technology: an overview and prospectus

ST Crooke, BF Baker, RM Crooke… - Nature reviews Drug …, 2021‏ - nature.com
Antisense technology is now beginning to deliver on its promise to treat diseases by
targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing …

Nucleic acid drugs: recent progress and future perspectives

X Sun, S Setrerrahmane, C Li, J Hu, H Xu - Signal Transduction and …, 2024‏ - nature.com
High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area
of investigation for decades. Currently, most clinically approved therapeutics are small …

[HTML][HTML] Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol

MT Neary, LM Mulder, PS Kowalski… - Journal of Controlled …, 2024‏ - Elsevier
In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …

[HTML][HTML] Basic, translational and clinical aspects of bronchiectasis in adults

JD Chalmers, S Elborn… - European Respiratory …, 2023‏ - publications.ersnet.org
Bronchiectasis is a common progressive respiratory disease with recognisable radiological
abnormalities and a clinical syndrome of cough, sputum production and recurrent respiratory …

MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapies

M Panda, E Kalita, S Singh, K Kumar, A Rao… - Life Sciences, 2022‏ - Elsevier
COVID-19 is a highly transmissible disease caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), affects 226 countries and continents, and has resulted in> 6.2 …

The challenges and opportunities in the development of MicroRNA therapeutics: a multidisciplinary viewpoint

MY Momin, RR Gaddam, M Kravitz, A Gupta, A Vikram - Cells, 2021‏ - mdpi.com
microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size,
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …

Drug discovery perspectives of antisense oligonucleotides

Y Kim - Biomolecules & therapeutics, 2023‏ - pmc.ncbi.nlm.nih.gov
The era of innovative RNA therapies using antisense oligonucleotides (ASOs), siRNAs, and
mRNAs is beginning. Since the emergence of the concept of ASOs in 1978, it took more than …

[HTML][HTML] One size does not fit all: the past, present and future of cystic fibrosis causal therapies

MM Ensinck, MS Carlon - Cells, 2022‏ - mdpi.com
Cystic fibrosis (CF) is the most common monogenic disorder, caused by mutations in the CF
transmembrane conductance regulator (CFTR) gene. Over the last 30 years, tremendous …

Non-coding RNA-directed therapeutics in lung cancer: delivery technologies and clinical applications

AAH Abdellatif, G Scagnetti, MA Younis… - Colloids and Surfaces B …, 2023‏ - Elsevier
Lung cancer is one of the most aggressive and deadliest health threats. There has been an
increasing interest in non-coding RNA (ncRNA) recently, especially in the areas of …

[HTML][HTML] Development of inhalable ATRA-loaded PLGA nanoparticles as host-directed immunotherapy against tuberculosis

AZ Bahlool, S Fattah, A O'Sullivan, B Cavanagh… - Pharmaceutics, 2022‏ - mdpi.com
Develo** new effective treatment strategies to overcome the rise in multi-drug resistant
tuberculosis cases (MDR-TB) represents a global challenge. A host-directed therapy (HDT) …