Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a
moiety of great significance. It forms an important intermediate in many industrial and …

ABSTRACT Introduction: The transcription factor Nrf2 (nuclear factor erythroid 2-related
factor 2) is the first line of defense against a plethora of environmental or endogenous …

Parent pentacyclic triterpenoic acids such as ursolic-, oleanolic, glycyrrhetinic, betulinic and
boswellic acid were converted into their acetylated piperazinyl amides that were coupled …

Multidrug resistance (MDR) in cancer remains a critical obstacle for efficient chemotherapy.
Many MDR reversal agents have been discovered but failed in clinical trials due to severe …

Natural products have been proven as the main source of biologically active compounds,
which are potentially useful for drug development. As one of the most studied pentacyclic …

Pentacyclic triterpenoids, as important representatives of natural products, have garnered
widespread attention due to their diverse biological activities, including anti-inflammatory …

α-Mangostin, a natural xanthone, was found to have anticancer effects, but these effects are
not sufficient to be effective. To increase anticancer potential and selectivity, a …

Colorectal cancer (CRC) is one of the most common malignancies, and multidrug resistance
(MDR) reduces the efficiency of anticancer drugs. Therefore, the development of novel …

Efficient and mild synthetic routes for bioactive natural product derivatives are of current
interest for drug discovery. Herein, on the basis of the pharmacophore hybrid strategy, we …

Abstract Alkylation of 5-(3, 3-R, R′-2-oxido-1-triazeneoxymethyl) tetrazole salts with
iodomethane, dimethyl sulfate, chloroacetonitrile, and 1-chloromethoxy-3, 3-dimethyl-1 …