Gut-derived metabolite, trimethylamine-N-oxide (TMAO) in cardio-metabolic diseases: detection, mechanism, and potential therapeutics
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …
Cardiac endothelium–myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction
Heart failure (HF) is an important global health problem with great socioeconomic burden.
Outcomes remain sub-optimal. Endothelium–cardiomyocyte interactions play essential roles …
Outcomes remain sub-optimal. Endothelium–cardiomyocyte interactions play essential roles …
Vascular actions of relaxin: nitric oxide and beyond
The peptide hormone relaxin regulates the essential maternal haemodynamic adaptations
in early pregnancy through direct actions on the renal and systemic vasculature. These …
in early pregnancy through direct actions on the renal and systemic vasculature. These …
The actions of relaxin on the human cardiovascular system
M Sarwar, XJ Du, TB Dschietzig… - British Journal of …, 2017 - Wiley Online Library
The insulin‐like peptide relaxin, originally identified as a hormone of pregnancy, is now
known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic …
known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic …
[HTML][HTML] Relaxin elicits renoprotective actions accompanied by increasing bile acid levels in streptozotocin-induced diabetic mice
Background The peptide hormone relaxin has potent anti-fibrotic and anti-inflammatory
properties in various organs, including the kidneys. However, the protective effects of relaxin …
properties in various organs, including the kidneys. However, the protective effects of relaxin …
Pressurized hot water extraction of okra seeds reveals antioxidant, antidiabetic and vasoprotective activities
Abelmoschus esculentus L. Moench (okra) is a commonly consumed vegetable that consists
of the seeds and peel component which are rich in polyphenolic compounds. The aim of this …
of the seeds and peel component which are rich in polyphenolic compounds. The aim of this …
Endothelium-dependent relaxation is impaired in Schlager hypertensive (BPH/2J) mice by region-specific mechanisms in conductance and resistance arteries
Aims Endothelial dysfunction and arterial stiffness are hallmarks of hypertension, and major
risk factors for cardiovascular disease. BPH/2J (Schlager) mice are a genetic model of …
risk factors for cardiovascular disease. BPH/2J (Schlager) mice are a genetic model of …
Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes
Serelaxin prevents endothelial dysfunction in the mouse aorta ex vivo and inhibits apoptosis
in cardiomyocytes under acute hyperglycaemia. Less is known about the effects of serelaxin …
in cardiomyocytes under acute hyperglycaemia. Less is known about the effects of serelaxin …
Antioxidant and Cytoprotective Effect of Quinoa (Chenopodium quinoa Willd.) with Pressurized Hot Water Extraction (PHWE)
Quinoa is widely noted for its nutritional value. The seed is the main edible part of the plant
and exists in at least three different colors: white, red and black. This study utilized a …
and exists in at least three different colors: white, red and black. This study utilized a …
The role of angiotensin II and relaxin in vascular adaptation to pregnancy
In brief There is a pregnancy-induced vasodilation of blood vessels, which is known to have
a protective effect on cardiovascular function and can be maintained postpartum. This …
a protective effect on cardiovascular function and can be maintained postpartum. This …