Animal models of pulmonary hypertension: Getting to the heart of the problem

JP Dignam, TE Scott, BK Kemp‐Harper… - British Journal of …, 2022 - Wiley Online Library
Despite recent therapeutic advances, pulmonary hypertension (PH) remains a fatal disease
due to the development of right ventricular (RV) failure. At present, no treatments targeted at …

Chronic thromboembolic pulmonary Hypertension–What have we learned from large animal models

K Stam, S Clauss, YJHJ Taverne… - Frontiers in …, 2021 - frontiersin.org
Chronic thrombo-embolic pulmonary hypertension (CTEPH) develops in a subset of patients
after acute pulmonary embolism. In CTEPH, pulmonary vascular resistance, which is initially …

Subject-specific one-dimensional fluid dynamics model of chronic thromboembolic pulmonary hypertension

A Kachabi, MJ Colebank, NC Chesler - Biomechanics and Modeling in …, 2024 - Springer
Chronic thromboembolic pulmonary hypertension (CTEPH) develops due to the
accumulation of blood clots in the lung vasculature that obstructs flow and increases …

Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle

K Stam, Z Cai, N van Der Velde… - The Journal of …, 2019 - Wiley Online Library
Key points Right ventricle (RV) function is the most important determinant of survival and
quality of life in patients with chronic thromboembolic pulmonary hypertension (CTEPH). The …

[HTML][HTML] Cell landscape atlas for patients with chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy constructed using single-cell RNA …

R Miao, X Dong, J Gong, Y Li, X Guo, J Wang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
This study aimed to construct an atlas of the cell landscape and comprehensively
characterize the cellular repertoire of the pulmonary endarterectomized tissues of patients …

Model of chronic thromboembolic pulmonary hypertension in rats caused by repeated intravenous administration of partially biodegradable sodium alginate …

AA Karpov, NA Anikin, AM Mihailova… - International Journal of …, 2021 - mdpi.com
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and life-threatening
complication of pulmonary embolism. As existing animal models of CTEPH do not fully …

[HTML][HTML] Mid-regional pro-atrial natriuretic peptide and copeptin as indicators of disease severity and therapy response in CTEPH

SD Kriechbaum, L Scherwitz… - ERJ Open …, 2020 - Eur Respiratory Soc
Background Chronic thromboembolic pulmonary hypertension (CTEPH) leads to right heart
failure. Pulmonary endarterectomy (PEA) or balloon pulmonary angioplasty (BPA) restore …

Chronic thromboembolic pulmonary hypertension: the bench

GA Alba, D Atri, S Darbha, I Singh, VF Tapson… - Current Cardiology …, 2021 - Springer
Abstract Purpose of Review Chronic thromboembolic pulmonary hypertension (CTEPH) is
an uncommon complication of acute pulmonary embolism (PE), in which the red, platelet …

Establishment of adult right ventricle failure in ovine using a graded, animal‐specific pulmonary artery constriction model

M Nguyen‐Truong, W Liu, J Boon… - Animal Models and …, 2020 - Wiley Online Library
Background Right ventricle failure (RVF) is associated with serious cardiac and pulmonary
diseases that contribute significantly to the morbidity and mortality of patients. Currently, the …

Markov Chain Monte Carlo with Gaussian Process Emulation for a 1D Hemodynamics Model of CTEPH

A Kachabi, MJ Colebank, SA Correa… - arxiv preprint arxiv …, 2024 - arxiv.org
Microvascular disease is a contributor to persistent pulmonary hypertension in those with
chronic thromboembolic pulmonary hypertension (CTEPH). The heterogenous nature of the …