Application of next generation sequencing for diagnosis and clinical management of drug-resistant tuberculosis: updates on recent developments in the field
N Dookie, A Khan, N Padayatchi, K Naidoo - Frontiers in microbiology, 2022 - frontiersin.org
The World Health Organization's End TB Strategy prioritizes universal access to an early
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …
Delamanid or pretomanid? A Solomonic judgement!
SE Mudde, AM Upton, A Lenaerts, HI Bax… - Journal of …, 2022 - academic.oup.com
Given the low treatment success rates of drug-resistant tuberculosis (TB), novel TB drugs are
urgently needed. The landscape of TB treatment has changed considerably over the last …
urgently needed. The landscape of TB treatment has changed considerably over the last …
Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis
Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …
largest single contributor to human mortality due to antimicrobial resistance. A few major …
[CARTE][B] Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance
World Health Organization - 2023 - books.google.com
Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid
A Bateson, J Ortiz Canseco, TD McHugh… - Journal of …, 2022 - academic.oup.com
Objectives To develop a robust phenotypic antimicrobial susceptibility testing (AST) method
with a correctly set breakpoint for pretomanid (Pa), the most recently approved anti …
with a correctly set breakpoint for pretomanid (Pa), the most recently approved anti …
Baseline and acquired resistance to bedaquiline, linezolid and pretomanid, and impact on treatment outcomes in four tuberculosis clinical trials containing pretomanid
J Timm, A Bateson, P Solanki, A Paleckyte… - PLOS Global Public …, 2023 - journals.plos.org
Bedaquiline (B), pretomanid (Pa) and linezolid (L) are key components of new regimens for
treating rifampicin-resistant tuberculosis (TB). However, there is limited information on the …
treating rifampicin-resistant tuberculosis (TB). However, there is limited information on the …
Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest infectious
diseases worldwide. Multidrug and extensively drug-resistant strains are making disease …
diseases worldwide. Multidrug and extensively drug-resistant strains are making disease …
Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance
The emergence of drug resistance continues to afflict TB control where drug resistant strains
have become a global health concern. Contrary to drug-sensitive TB, the treatment of …
have become a global health concern. Contrary to drug-sensitive TB, the treatment of …
Mechanism of Action, Resistance, Synergism, and Clinical Implications of Delamanid Against Multidrug-Resistant Mycobacterium tuberculosis
Multidrug-resistant (MDR) isolates of Mycobacterium tuberculosis (MTB) remain a primary
global threat to the end of tuberculosis (TB) era. Delamanid (DLM) is a nitro-dihydro …
global threat to the end of tuberculosis (TB) era. Delamanid (DLM) is a nitro-dihydro …
Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance
A total of 1.6 million people died of tuberculosis (TB) in 2021, and approximately 10.6 million
people developed active TB disease due to Mycobacterium tuberculosis complex (MTBC) …
people developed active TB disease due to Mycobacterium tuberculosis complex (MTBC) …