CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …
promising immunotherapeutic approach to fight cancers. This approach consists of …
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …
considered as specialized immune cells that can be genetically modified to obtain capable …
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
Adult somatic tissues have proven difficult to expand in vitro, largely because of the
complexity of recreating appropriate environmental signals in culture. We have overcome …
complexity of recreating appropriate environmental signals in culture. We have overcome …
LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus
D Finkelshtein, A Werman, D Novick… - Proceedings of the …, 2013 - National Acad Sciences
Vesicular stomatitis virus (VSV) exhibits a remarkably robust and pantropic infectivity,
mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV …
mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV …
Clinical, virologic, and immunologic evaluation of symptomatic coronavirus disease 2019 rebound following nirmatrelvir/ritonavir treatment
Background Nirmatrelvir/ritonavir, the first severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) protease inhibitor, reduces the risk of hospitalization and death by …
(SARS-CoV-2) protease inhibitor, reduces the risk of hospitalization and death by …
Engineering NK cells for CAR therapy—recent advances in gene transfer methodology
P Schmidt, MJ Raftery, G Pecher - Frontiers in Immunology, 2021 - frontiersin.org
The development of chimeric antigen receptor (CAR) T cell therapy has introduced a new
and effective strategy to guide and promote the immune response against tumors in the …
and effective strategy to guide and promote the immune response against tumors in the …
You have got a fast CAR: chimeric antigen receptor NK cells in cancer therapy
The clinical success stories of chimeric antigen receptor (CAR)-T cell therapy against B-cell
malignancies have contributed to immunotherapy being at the forefront of cancer therapy …
malignancies have contributed to immunotherapy being at the forefront of cancer therapy …
Chimeric antigen receptor engineered natural killer cells for cancer therapy
Y Zhang, W Zhou, J Yang, J Yang, W Wang - Experimental Hematology & …, 2023 - Springer
Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …
Viral and nonviral engineering of natural killer cells as emerging adoptive cancer immunotherapies
S Matosevic - Journal of immunology research, 2018 - Wiley Online Library
Natural killer (NK) cells are powerful immune effectors whose antitumor activity is regulated
through a sophisticated network of activating and inhibitory receptors. As effectors of cancer …
through a sophisticated network of activating and inhibitory receptors. As effectors of cancer …
“UniCAR”-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells
Antigen-specific redirection of immune effector cells with chimeric antigen receptors (CARs)
demonstrated high therapeutic potential for targeting cancers of different origins. Beside …
demonstrated high therapeutic potential for targeting cancers of different origins. Beside …