The nuclear factor kappa B (NF-êB) family of transcription factors plays an essential role as
stressors in the cellular environment, and controls the expression of important regulatory …

Clefts of the lip and palate (CLP), the major causes of congenital facial malformation
globally, result from failure of fusion of the facial processes during embryogenesis. With a …

Nonsyndromic orofacial clefts (OFCs) are a heterogeneous group of common craniofacial
birth defects with complex etiologies that include genetic and environmental risk factors …

Abstract Development of the human skull and face is a highly orchestrated and complex
three-dimensional morphogenetic process, involving hundreds of genes controlling the …

The integrity of the mammalian epidermis depends on a balance of proliferation and
differentiation in the resident population of stem cells. The kinase RIPK4 and the …

Abstract Development of the secondary palate involves a complex series of embryonic
events which, if disrupted, result in the common congenital anomaly cleft palate. The …

Tissue homeostasis of skin is sustained by epidermal progenitor cells localized within the
basal layer of the skin epithelium. Post‐translational modification of the proteome, such as …

The receptor-interacting protein kinase 4 (RIPK4), a member of the RIPK family, was
originally described as an interaction partner of protein kinase C (PKC) β and PKCδ. RIPK4 …

Terminal differentiation of epithelial cells is critical for the barrier function of the skin, the
growth of skin appendages, such as hair and nails, and the development of the skin of …

Prenatal stress and poor maternal mental health are associated with adverse offspring
outcomes; however, the biological mechanisms are unknown. Epigenetic modification has …