The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

The mammalian brain depends upon glucose as its main source of energy, and tight
regulation of glucose metabolism is critical for brain physiology. Consistent with its critical …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …

Breakthrough technologies to measure cellular oxygen consumption and proton efflux are
reigniting the study of cellular energetics by increasing the scope and pace with which …

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The ketogenic diet (KD) restricts carbohydrate consumption, leading to an increase in
ketone bodies, such as acetoacetate, β-hydroxybutyrate, and acetone, which are utilized as …

Alzheimer's disease (AD) starts from pure cognitive impairments and gradually progresses
into degeneration of specific brain circuits. Although numerous factors initiating AD have …

Abstract β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …

Epilepsy is a complex neurological syndrome characterized by neuronal hyperexcitability
and sudden, synchronized electrical discharges that can manifest as seizures. It is now …