Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as …

Apicomplexan parasites are leading causes of human and livestock diseases such as
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …

Apicomplexa are obligatory intracellular parasites that sense and actively invade host cells.
Invasion is a conserved process that relies on the timely and spatially controlled exocytosis …

Protein kinases regulate fundamental aspects of eukaryotic cell biology, making them
attractive chemotherapeutic targets in parasites like Plasmodium spp. and Toxoplasma …

One of the hallmarks of the parasitic phylum of Apicomplexa is the presence of highly
specialised, apical secretory organelles, called the micronemes and rhoptries that play …

Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a
key building block of phospholipid synthesis and a major lipid second messenger conveying …

Rhoptries are specialized secretory organelles found in the Apicomplexa phylum, playing a
central role in the establishment of parasitism. The rhoptry content includes membranous as …

Toxoplasma virulence depends on its ability to evade or survive the toxoplasmacidal
mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved …

Apicomplexa exhibit a unique form of substrate-dependent gliding motility central for host
cell invasion and parasite dissemination. Gliding is powered by rearward translocation of …