Growth plate chondrocytes play a pivotal role in promoting longitudinal bone growth. The
current review represents a brief survey of the phenomena involved in this process at the …

Improved technologies have led to the isolation of a large number of noncollagenous matrix
proteins from the mineralized connective tissues. These proteins have been postulated to …

We have investigated the ability of exogenous transforming growth factor-/3 (TGF-/3) to
induce osteogenesis and chondrogenesis, critical events in both bone formation and …

During the process of endochondral bone formation, proliferating chondrocytes give rise to
hypertrophic cells, which then deposit a mineralized matrix to form calcified cartilage prior to …

Data obtained while investigating growth plate chondrocyte differentiation during
endochondral bone formation both in vivo and in vitro indicate that initial chondrogenesis …

Using an in vitro model of rat epiphyseal chrondrocyte differentiation in which cells are
maintained in a three-dimensional cell pellet, we show that exogenous TGF-β1 reversibly …

Extracellular matrix (ECM) acts as an instructing template for the cells contained in tissues. It
plays a vital role in regulating cellular behavior by holding and interacting with various …

We have examined the ability of dexamethasone, retinoic acid, and vitamin D3 to induce
osteogenic differentiation in rat marrow stromal cell cultures by measuring the expression of …

Endochondral bone formation is one of the most extensively examined developmental
sequences within vertebrates. This process involves the coordinated temporal/spatial …

During the process of endochondral bone formation, proliferating chondrocytes give rise to
hypertrophic chondrocytes, which then deposit a mineralized matrix to form calcified …