Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development
and function and are characterized by wide genetic and clinical variability. In this review, we …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Genes involved in synaptic function are enriched among those with autism spectrum
disorder (ASD)-associated rare genetic variants. Dysregulated cortical neurogenesis has …

In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …

Liquid–liquid phase separation (LLPS) of SynGAP and PSD-95, two abundant proteins that
interact in the postsynaptic density (PSD) of neurons, has been implicated in modulating …

SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic
plasticity, learning, memory, and cognition. Mutations in SYNGAP1 in humans result in …

Dravet syndrome is an intractable developmental and epileptic encephalopathy caused by
de novo variants in SCN1A resulting in haploinsufficiency of the voltage-gated sodium …

Alternative splicing of neuronal genes is controlled partly by the coordinated action of
polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed …

Human brain ontogeny is characterized by a considerably prolonged neotenic development
of cortical neurons and circuits. Neoteny is thought to be essential for the acquisition of …

Protein O-glycosylation is widely identified in various proteins involved in diverse biological
processes. Recent studies have demonstrated that O-glycosylation plays crucial and …