Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …

Diabetes mellitus (DM) displays a high morbidity. The diabetic heart is susceptible to
myocardial ischemia/reperfusion (MI/R) injury. Impaired activation of prosurvival pathways …

The mammalian target of rapamycin (mTOR), the key component of the protein complexes
mTORC1 and mTORC2, plays a critical role in cellular development, tissue regeneration …

Statins are currently able to stabilize atherosclerotic plaques by lowering plasma cholesterol
and pleiotropic effects, but a residual risk for atherosclerotic disease remains. Therefore …

After renal transplantation, hemolytic uremic syndrome (HUS) may occur either as a
recurrent or de novo form. Over the past decade, much effort has been devoted to …

Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR)
and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very …

Thrombotic microangiopathies (TMA) constitute a group of different disorders that have a
common underlying mechanism: the endothelial damage. These disorders may exhibit …

Thrombotic microangiopathy (TMA) is a serious complication of transplantation that
adversely affects kidney transplant recipient and allograft survival. Post-transplant TMA is …

The mammalian target of rapamycin (mTOR) and its associated cell signaling pathways
have garnered significant attention for their roles in cell biology and oncology. Interestingly …

Thrombotic microangiopathy is a rare but serious complication that affects kidney transplant
recipients. It appears in 0.8–14% of transplanted patients and negatively affects graft and …