Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …

Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of
glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important …

Carbohydrates possess a variety of distinct features with stereochemistry playing a
particularly important role in distinguishing their structure and function. Monosaccharide …

Protein biopharmaceuticals are macromolecules with a therapeutic effect, commonly
produced by the recombinant DNA technology. They have emerged as important …

Proteins can undergo glycosylation during and/or after translation to afford glycoconjugates,
which are often secreted by a cell or populate cell surfaces. Changes in the glycan portion …

The N-linked glycosylation of the constant fragment (Fc) of immunoglobulin G has been
shown to change during pathological and physiological events and to strongly influence …

Therapeutic monoclonal antibodies (mAbs) are glycoproteins produced by living cell
systems. The glycan moieties attached to the proteins can directly affect protein stability …