Polyamines are essential for the growth and proliferation of mammalian cells and are
intimately involved in biological mechanisms such as DNA replication, RNA transcription …

Highlights•Calcium homeostasis is crucial in cancer, regulating many physiological
processes.•Calcium ion-related channels are crucial in cancer regulation and potential …

Store‐operated Ca2+ entry (SOCE) is a major mechanism for Ca2+ influx in colorectal
cancer (CRC) cells. This mechanism, regulated by the filling state of the intracellular Ca2+ …

Polyamines (PA) are polycations with pleiotropic functions in cellular physiology and
pathology. In particular, PA have been involved in the regulation of cell homeostasis and …

Immune cells-enhanced immunotherapy exhibits unprecedented overall survival-
prolongation even curable in some cancer patients. Although so, most of the patients show …

Concerning the progression of societies and the evolution of lifestyle and dietary habits, the
potential for the development of human malignancies, particularly colorectal cancer (CRC) …

Most cancer cells show the Warburg effect, the rewiring of aerobic metabolism to glycolysis
due to defective mitochondrial ATP synthesis. As a consequence, tumor cells display …

Simple Summary Breast cancer is one of the most common types of cancer in women.
Breast tumors can be grouped in, at least, three different molecular subtypes, including …

Extended synaptotagmins (E-Syts) are endoplasmic reticulum (ER)-associated proteins that
facilitate the tethering of the ER to the plasma membrane (PM), participating in lipid transfer …

Altered metabolism is one of the key molecular characteristics of prostate cancer (PCa). The
search for new tissue biomarkers that could be used for diagnosis, assessment of …