Trace amines and their receptors
Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …
[HTML][HTML] Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges
The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
The structural basis of odorant recognition in insect olfactory receptors
Olfactory systems must detect and discriminate amongst an enormous variety of odorants.
To contend with this challenge, diverse species have converged on a common strategy in …
To contend with this challenge, diverse species have converged on a common strategy in …
Structural basis of amine odorant perception by a mammal olfactory receptor
L Guo, J Cheng, S Lian, Q Liu, Y Lu, Y Zheng, K Zhu… - Nature, 2023 - nature.com
Odorants are detected as smell in the nasal epithelium of mammals by two G-protein-
coupled receptor families, the odorant receptors and the trace amine-associated …
coupled receptor families, the odorant receptors and the trace amine-associated …
Wireless portable bioelectronic nose device for multiplex monitoring toward food freshness/spoilage
Monitoring food freshness/spoilage is important to ensure food quality and safety. Current
methods of food quality monitoring are mostly time-consuming and labor intensive …
methods of food quality monitoring are mostly time-consuming and labor intensive …
Engineered odorant receptors illuminate the basis of odour discrimination
How the olfactory system detects and distinguishes odorants with diverse physicochemical
properties and molecular configurations remains poorly understood. Vertebrate animals …
properties and molecular configurations remains poorly understood. Vertebrate animals …
Visualizing the GPCR network: classification and evolution
In this study, we delineate an unsupervised clustering algorithm, minimum span clustering
(MSC), and apply it to detect G-protein coupled receptor (GPCR) sequences and to study the …
(MSC), and apply it to detect G-protein coupled receptor (GPCR) sequences and to study the …
Structural and signaling mechanisms of TAAR1 enabled preferential agonist design
P Shang, N Rong, JJ Jiang, J Cheng, MH Zhang… - Cell, 2023 - cell.com
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …
The evolving neural and genetic architecture of vertebrate olfaction
Evolution sculpts the olfactory nervous system in response to the unique sensory challenges
facing each species. In vertebrates, dramatic and diverse adaptations to the chemical …
facing each species. In vertebrates, dramatic and diverse adaptations to the chemical …
Structure-Based Discovery of Mouse Trace Amine-Associated Receptor 5 Antagonists
A Nicoli, V Weber, C Bon, A Steuer… - Journal of Chemical …, 2023 - ACS Publications
Trace amine-associated receptors (TAARs) were discovered in 2001 as new members of
class AG protein-coupled receptors (GPCRs). With the only exception of TAAR1, TAAR …
class AG protein-coupled receptors (GPCRs). With the only exception of TAAR1, TAAR …