Trace amines and their receptors

RR Gainetdinov, MC Hoener, MD Berry… - Pharmacological …, 2018 - Elsevier
Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …

[HTML][HTML] Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges

MD Berry, RR Gainetdinov, MC Hoener… - Pharmacology & …, 2017 - Elsevier
The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …

The structural basis of odorant recognition in insect olfactory receptors

J Del Mármol, MA Yedlin, V Ruta - Nature, 2021 - nature.com
Olfactory systems must detect and discriminate amongst an enormous variety of odorants.
To contend with this challenge, diverse species have converged on a common strategy in …

Structural basis of amine odorant perception by a mammal olfactory receptor

L Guo, J Cheng, S Lian, Q Liu, Y Lu, Y Zheng, K Zhu… - Nature, 2023 - nature.com
Odorants are detected as smell in the nasal epithelium of mammals by two G-protein-
coupled receptor families, the odorant receptors and the trace amine-associated …

Wireless portable bioelectronic nose device for multiplex monitoring toward food freshness/spoilage

KH Kim, D Moon, JE An, SJ Park, SE Seo, S Ha… - Biosensors and …, 2022 - Elsevier
Monitoring food freshness/spoilage is important to ensure food quality and safety. Current
methods of food quality monitoring are mostly time-consuming and labor intensive …

Engineered odorant receptors illuminate the basis of odour discrimination

CA de March, N Ma, CB Billesbølle, J Tewari… - Nature, 2024 - nature.com
How the olfactory system detects and distinguishes odorants with diverse physicochemical
properties and molecular configurations remains poorly understood. Vertebrate animals …

Visualizing the GPCR network: classification and evolution

GM Hu, TL Mai, CM Chen - Scientific reports, 2017 - nature.com
In this study, we delineate an unsupervised clustering algorithm, minimum span clustering
(MSC), and apply it to detect G-protein coupled receptor (GPCR) sequences and to study the …

Structural and signaling mechanisms of TAAR1 enabled preferential agonist design

P Shang, N Rong, JJ Jiang, J Cheng, MH Zhang… - Cell, 2023 - cell.com
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …

The evolving neural and genetic architecture of vertebrate olfaction

DM Bear, JM Lassance, HE Hoekstra, SR Datta - Current Biology, 2016 - cell.com
Evolution sculpts the olfactory nervous system in response to the unique sensory challenges
facing each species. In vertebrates, dramatic and diverse adaptations to the chemical …

Structure-Based Discovery of Mouse Trace Amine-Associated Receptor 5 Antagonists

A Nicoli, V Weber, C Bon, A Steuer… - Journal of Chemical …, 2023 - ACS Publications
Trace amine-associated receptors (TAARs) were discovered in 2001 as new members of
class AG protein-coupled receptors (GPCRs). With the only exception of TAAR1, TAAR …