Multiomics to elucidate inflammatory bowel disease risk factors and pathways

M Agrawal, KH Allin, F Petralia, JF Colombel… - Nature reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …

Glycosylation: mechanisms, biological functions and clinical implications

M He, X Zhou, X Wang - Signal Transduction and Targeted Therapy, 2024 - nature.com
Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

High-throughput glycomic methods

I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

MR Kudelka, SR Stowell, RD Cummings… - Nature reviews …, 2020 - nature.com
Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

S Shkunnikova, A Mijakovac, L Sironic, M Hanic… - Biotechnology …, 2023 - Elsevier
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …

[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases

I Gudelj, G Lauc, M Pezer - Cellular Immunology, 2018 - Elsevier
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …

Impact of structural modifications of IgG antibodies on effector functions

T Damelang, M Brinkhaus, TLJ van Osch… - Frontiers in …, 2024 - frontiersin.org
Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system,
binding to and neutralizing pathogens and other foreign substances. Recent advances in …

Repurposing the CRISPR-Cas9 system for targeted DNA methylation

A Vojta, P Dobrinić, V Tadić, L Bočkor… - Nucleic acids …, 2016 - academic.oup.com
Epigenetic studies relied so far on correlations between epigenetic marks and gene
expression pattern. Technologies developed for epigenome editing now enable direct study …

IgA and FcαRI: pathological roles and therapeutic opportunities

A Breedveld, M Van Egmond - Frontiers in immunology, 2019 - frontiersin.org
Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

Plasma markers of disrupted gut permeability in severe COVID-19 patients

LB Giron, H Dweep, X Yin, H Wang, M Damra… - Frontiers in …, 2021 - frontiersin.org
A disruption of the crosstalk between the gut and the lung has been implicated as a driver of
severity during respiratory-related diseases. Lung injury causes systemic inflammation …