Innovations in information and communication technology infuse all branches of science,
including life sciences. Nevertheless, healthcare is historically slow in adopting …

Bone is a unique tissue with turnover, metabolic, and cellular activities that vary through
development to aging and with a mineralized matrix in which the current state and the …

Bone formation during fracture repair inevitably initiates within or around extravascular
deposits of a fibrin-rich matrix. In addition to a central role in hemostasis, fibrin is thought to …

Degenerative disc disease (DDD) is associated with intervertebral disc degeneration of
spinal instability. Here, we report that the cilia of nucleus pulposus (NP) cells mediate …

Multiple myeloma (MM) patients frequently develop tumor-induced bone destruction, yet no
therapy completely eliminates the tumor or fully reverses bone loss. Transforming growth …

All levels of the unique hierarchical structure of bone, consisting of collagen and
hydroxyapatite crystals at the nanoscale to osteon/lamellae structures at the microscale …

In addition to the loss in bone volume that occurs with age, there is a decline in material
properties. To test new therapies or diagnostic tools that target such properties as material …

New treatments for bone diseases require testing in animal models before clinical
translation, and the mouse tibia is among the most common models. In vivo micro-Computed …

Combination therapy with bisphosphonates and vitamin D 3 analogs has been frequently
used for the treatment of osteoporosis. However, its effects on bone anisotropies, such as …

As a dedicated experimentalist, John Currey praised the high potential of finite element (FE)
analysis but also recognized its critical limitations. The application of the FE methodology to …