Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

The 26S proteasome is involved in degrading and regulating the majority of proteins in
eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this …

Ubiquitin regulates various cellular functions by posttranslationally modifying substrates with
diverse ubiquitin codes. Recent discoveries of new ubiquitin chain topologies, types of …

Ubiquitination is the major criteria for the recognition of a substrate-protein by the 26S
proteasome. Additionally, a disordered segment on the substrate—either intrinsic or induced …

The recent revolution in computational protein structure prediction provides folding models
for entire proteomes, which can now be integrated with large-scale experimental data. Mass …

The ubiquitin-proteasome system (UPS) is critical for protein quality control and regulating
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …

Ubiquitin signaling is a sequence of events driving the fate of a protein based on the type of
ubiquitin modifications attached. In the case of neurodegenerative diseases, ubiquitin …

As an important regulator of intracellular protein degradation, the mechanism of the
deubiquitinating enzyme family in tumour metastasis has received increasing attention. Our …

EGFR inhibitor therapies have brought significant benefit to NSCLC patients. However, all
patients gradually progress to acquired resistance via diverse mechanisms. Akt3 …

OTU domain-containing ubiquitin aldehyde-binding proteins 1 (OTUB1) is the most
important element of the deubiquitinase OTU superfamily, which has been identified as an …