Introduction Oxidative stress and inflammation are known to play a critical role in ageing and
chronic disease development and could therefore represent important targets for develo** …

Mammalian cells respond to stress by activating mechanisms that support cellular functions
and hence maintain microenvironmental and organismal homeostasis. Intracellular …

Ageing is a major risk factor for develo** many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

The circadian rhythm is an evolutionarily conserved time-kee** system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Cellular theory of aging states that human aging is the result of cellular aging, in which an
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …

Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

Cancer is the principal cause of death and a dominant public health problem which
seriously threatening human life. Among various ways to treat cancer, traditional Chinese …

The genome is constantly attacked by genotoxic insults. DNA damage has long been
established as a cause of cancer development through its mutagenic consequences …

DNA damage plays a causal role in numerous human pathologies including cancer,
premature aging, and chronic inflammatory conditions. In response to genotoxic insults, the …

DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this
work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure …