Highlights•HBV HBx is required for virus replication.•Required HBx function (s) may vary
with the stage of chronic HBV infection.•HBx binding to DDB1 may impact several DDB1 …

Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …

Sterile alpha motif and HD-domain–containing protein 1 (SAMHD1) blocks replication of
retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has …

Rationale: Viruses hijack the host cell machinery to promote viral replication; however, the
mechanism by which metabolic reprogramming regulates innate antiviral immunity in the …

Cellular SAMHD1 inhibits replication of many viruses by limiting intracellular
deoxynucleoside triphosphate (dNTP) pools. We investigate the influence of SAMHD1 on …

Deregulated activity of the Src tyrosine kinases leads to malignant transformation. Since the
FDA approval of the tyrosine kinase inhibitor, imatinib, in 2001 for the treatment of chronic …

The hepatitis B virus (HBV) infects hepatocytes and hijacks host cellular mechanisms for its
replication. Host proteins can be frontline effectors of the cell's defense and restrict viral …

O-linked-β-DN-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation), which is
dynamically regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), is a post …

The SAM and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase
that plays a crucial role for a variety of different cellular functions. Besides balancing …

The host restriction factor sterile alpha motif and histidine–aspartate domain-containing
protein 1 (SAMHD1) is an important component of the innate immune system. By regulating …