Joint pain is the hallmark symptom of osteoarthritis (OA) and the main reason for patients to
seek medical assistance. OA pain greatly contributes to functional limitations of joints and …

Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting
physiology, motor function, and motivation to engage in certain behaviors. The complexity of …

The primary objective of preclinical pain research is to improve the treatment of pain.
Decades of research using pain-evoked tests has revealed much about mechanisms but …

Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that
blockade of afferent input from the injury with local anesthetic elicits conditioned place …

Pain is a major clinical problem of osteoarthritis (OA). Recently, OA has been thought to be a
disease of the whole joint with both destruction of cartilage and inflammatory components …

Objectives Osteoarthritis (OA) is the leading cause of musculoskeletal pain and functional
disability worldwide, affecting a growing number of individuals in the western society …

Relief from pain in humans is rewarding and pleasurable. Primary rewards, or reward-
predictive cues, are encoded in brain reward/motivational circuits. While considerable …

Objective Osteoarthritis (OA) is a complex and painful disease of the whole joint. At present
there are no satisfying agents for treating OA. To promote OA research and improved …