The future of early cancer detection

RC Fitzgerald, AC Antoniou, L Fruk, N Rosenfeld - Nature medicine, 2022 - nature.com
A proactive approach to detecting cancer at an early stage can make treatments more
effective, with fewer side effects and improved long-term survival. However, as detection …

Photon-counting detector CT: system design and clinical applications of an emerging technology

S Leng, M Bruesewitz, S Tao, K Rajendran… - Radiographics, 2019 - pubs.rsna.org
Photon-counting detector (PCD) CT is an emerging technology that has shown tremendous
progress in the last decade. Various types of PCD CT systems have been developed to …

Nanomaterials for in vivo imaging

BR Smith, SS Gambhir - Chemical reviews, 2017 - ACS Publications
In vivo imaging, which enables us to peer deeply within living subjects, is producing
tremendous opportunities both for clinical diagnostics and as a research tool. Contrast …

Multifunctional gold nanoparticles for diagnosis and therapy of disease

AJ Mieszawska, WJM Mulder, ZA Fayad… - Molecular …, 2013 - ACS Publications
Gold nanoparticles (AuNPs) have a number of physical properties that make them appealing
for medical applications. For example, the attenuation of X-rays by gold nanoparticles has …

Nano‐sized CT contrast agents

N Lee, SH Choi, T Hyeon - Advanced Materials, 2013 - Wiley Online Library
Computed tomography (CT) is one of the most widely used clinical imaging modalities. In
order to increase the sensitivity of CT, small iodinated compounds are used as injectable …

Nanoparticle contrast agents for computed tomography: a focus on micelles

DP Cormode, PC Naha… - Contrast media & …, 2014 - Wiley Online Library
Computed tomography (CT) is an X‐ray‐based whole‐body imaging technique that is
widely used in medicine. Clinically approved contrast agents for CT are iodinated small …

X-ray-based techniques to study the nano–bio interface

C Sanchez-Cano, RA Alvarez-Puebla, JM Abendroth… - ACS …, 2021 - ACS Publications
X-ray-based analytics are routinely applied in many fields, including physics, chemistry,
materials science, and engineering. The full potential of such techniques in the life sciences …

First experience with a whole-body spectral photon-counting CT clinical prototype

SA Si-Mohamed, S Boccalini, M Villien… - Investigative …, 2023 - journals.lww.com
Spectral photon-counting computed tomography (SPCCT) technology holds great promise
for becoming the next generation of computed tomography (CT) systems. Its technical …

Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies

BM Yeh, PF FitzGerald, PM Edic, JW Lambert… - Advanced drug delivery …, 2017 - Elsevier
The introduction of spectral CT imaging in the form of fast clinical dual-energy CT enabled
contrast material to be differentiated from other radiodense materials, improved lesion …

In vivo molecular K-edge imaging of atherosclerotic plaque using photon-counting CT

SA Si-Mohamed, M Sigovan, JC Hsu, V Tatard-Leitman… - Radiology, 2021 - pubs.rsna.org
Background Macrophage burden is a major factor in the risk of atherosclerotic plaque
rupture, and its evaluation remains challenging with molecular noninvasive imaging …