▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …

In 1876, von Kupffer described liver Sternzellen (star-shaped cells). The functions of these
cells remained enigmatic for 75 years until Ito observed lipid-containing perisinusoidal cells …

Plant defenses against pathogens and insects are regulated differentially by cross-
communicating signal transduction pathways in which salicylic acid (SA) and jasmonic acid …

Expanded adipose tissue mass increases the risk for many clinical conditions including
diabetes, hypertension, coronary atherosclerotic heart disease, and some forms of cancer …

The extracellular matrix (ECM) provides cells with positional information and a mechanical
scaffold for adhesion and migration. It consists of collagens, glycoproteins, proteoglycans …

Following chronic liver injury of any etiology, there is progressive fibrosis. To date, removing
the causative agent is the only effective therapy to stop or even reverse liver fibrosis …

Background & Aims: Hepatic myofibroblasts are central for the development of liver fibrosis
associated with chronic liver diseases, and blocking their accumulation may prevent …

The cyclooxygenase (COX, prostaglandin endoperoxide synthase) is a key enzyme in
prostaglandin biosynthesis. Two isoforms of COX, COX-1 and COX-2, have been identified …

Objectives: To provide an overview on: 1) the expression of cyclooxygenase (COX)-2 in
articular tissues; 2) the role of prostaglandin E2 (PGE2) in these tissue functions; and 3) …

Following acute or chronic liver tissue damage, hepatic stellate cells (HSCs) undergo a
process of activation toward a phenotype characterized by increased proliferation, motility …