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Obesity and cardiovascular disease: a scientific statement from the American Heart Association
The global obesity epidemic is well established, with increases in obesity prevalence for
most countries since the 1980s. Obesity contributes directly to incident cardiovascular risk …
most countries since the 1980s. Obesity contributes directly to incident cardiovascular risk …
Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Adipose tissue as a linchpin of organismal ageing
Ageing is a conserved biological process, modulated by intrinsic and extrinsic factors, that
leads to changes in life expectancy. In humans, ageing is characterized by greatly increased …
leads to changes in life expectancy. In humans, ageing is characterized by greatly increased …
Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue: JACC State-of-the-Art Review
Obesity is a significant risk factor for arrhythmic cardiovascular death. Interactions between
epicardial adipose tissue (EAT) and myocytes are thought to play a key role in the …
epicardial adipose tissue (EAT) and myocytes are thought to play a key role in the …
Atrial fibrillation is associated with the fibrotic remodelling of adipose tissue in the subepicardium of human and sheep atria
P Haemers, H Hamdi, K Guedj, N Suffee… - European heart …, 2017 - academic.oup.com
Aims Accumulation of atrial adipose tissue is associated with atrial fibrillation (AF). However,
the underlying mechanisms remain poorly understood. We examined the relationship …
the underlying mechanisms remain poorly understood. We examined the relationship …
Fat infiltration in the infarcted heart as a paradigm for ventricular arrhythmias
Infiltrating adipose tissue (inFAT) has been recently found to co-localize with scar in
infarcted hearts and may contribute to ventricular arrhythmias (VAs), a life-threatening heart …
infarcted hearts and may contribute to ventricular arrhythmias (VAs), a life-threatening heart …
The living scar–cardiac fibroblasts and the injured heart
Cardiac scars, often dubbed 'dead tissue', are very much alive, with heterocellular activity
contributing to the maintenance of structural and mechanical integrity following heart injury …
contributing to the maintenance of structural and mechanical integrity following heart injury …
Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium
Sudden blockage of arteries supplying the heart muscle contributes to millions of heart
attacks (myocardial infarction, MI) around the world. Although re-opening these arteries …
attacks (myocardial infarction, MI) around the world. Although re-opening these arteries …
Mechanisms and drug development in atrial fibrillation
Atrial fibrillation is a highly prevalent cardiac arrhythmia and the most important cause of
embolic stroke. Although genetic studies have identified an increasing assembly of AF …
embolic stroke. Although genetic studies have identified an increasing assembly of AF …
Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction
Although cardiac action potential (AP) generation and propagation have traditionally been
attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable …
attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable …