Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO2/H+ detected within the brain. Interest in central chemoreception has grown …

By definition central respiratory chemoreceptors (CRCs) are cells that are sensitive to
changes in brain PCO2 or pH and contribute to the stimulation of breathing elicited by …

There is a long-standing controversy about the role of serotonin in sleep/wake control, with
competing theories that it either promotes sleep or causes arousal. Here, we show that there …

Serotonergic (5-HT) neurons are putative central respiratory chemoreceptors, aiding in the
brain's ability to detect arterial changes in [Formula: see text] and implement appropriate …

The functional roles of the medullary raphé, and specifically 5-HT neurons, are not well
understood. It has previously been stated that the role of 5-HT has been so difficult to …

The sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality
in the United States, is typically associated with a sleep period. Previously, we showed …

An interoceptive homeostatic system monitors levels of CO2/H+ and provides a
proportionate drive to respiratory control networks that adjust lung ventilation to maintain …

Orexin, a small neuropeptide released from neurons in the hypothalamus with widespread
projections throughout the central nervous system, has broad biological roles including the …

Serotonergic neurones in the mammalian medullary raphe region (MRR) have been
implicated in central chemoreception and the modulation of the ventilatory response to …

The first two postnatal weeks are the most dynamic in the development of brain stem
respiratory nuclei in the rat, the primary model for this review. Several neurochemicals …