Rab family of small GTPases: an updated view on their regulation and functions
The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …
Regulation of host-pathogen interactions via the ubiquitin system
Ubiquitination is a posttranslational modification that regulates a multitude of cellular
functions. Pathogens, such as bacteria and viruses, have evolved sophisticated …
functions. Pathogens, such as bacteria and viruses, have evolved sophisticated …
Ubiquitination of Rheb governs growth factor-induced mTORC1 activation
Mechanistic target of rapamycin mTOR complex 1 (mTORC1) plays a key role in the
integration of various environmental signals to regulate cell growth and metabolism …
integration of various environmental signals to regulate cell growth and metabolism …
Regulation of phosphoribosyl-linked serine ubiquitination by deubiquitinases DupA and DupB
The family of bacterial SidE enzymes catalyzes non-canonical phosphoribosyl-linked (PR)
serine ubiquitination and promotes infectivity of Legionella pneumophila. Here, we describe …
serine ubiquitination and promotes infectivity of Legionella pneumophila. Here, we describe …
USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7
The endosomal system is a highly dynamic multifunctional organelle, whose complexity is
regulated in part by reversible ubiquitylation. Despite the wide-ranging influence of ubiquitin …
regulated in part by reversible ubiquitylation. Despite the wide-ranging influence of ubiquitin …
K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins
The RAS pathway is among the most frequently activated signaling nodes in cancer.
However, the mechanisms that alter RAS activity in human pathologies are not entirely …
However, the mechanisms that alter RAS activity in human pathologies are not entirely …
The regulation of the protein interaction network by monoubiquitination
W Magits, AA Sablina - Current Opinion in Structural Biology, 2022 - Elsevier
The conjugation of a single ubiquitin or monoubiquitination acts as a versatile signal that
can have both degradative and non-degradative functions. The latter is of particular interest …
can have both degradative and non-degradative functions. The latter is of particular interest …
The endosomal network: mediators and regulators of endosome maturation
Endocytosis is a means for the cell to sample its environment for nutrients and regulate
plasma membrane (PM) composition and area. Whereas the majority of internalized cargo is …
plasma membrane (PM) composition and area. Whereas the majority of internalized cargo is …
Requirement of Rab5 GTPase during heat stress-induced endocytosis in yeast
The plasma membrane (PM) is constantly exposed to various stresses from the extracellular
environment, such as heat and oxidative stress. These stresses often cause the denaturation …
environment, such as heat and oxidative stress. These stresses often cause the denaturation …
Cracking the monoubiquitin code of genetic diseases
Ubiquitination is a versatile and dynamic post-translational modification in which single
ubiquitin molecules or polyubiquitin chains are attached to target proteins, giving rise to …
ubiquitin molecules or polyubiquitin chains are attached to target proteins, giving rise to …