Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

There is increasing evidence that both mechanical and biochemical signals play important
roles in development and disease. The development of complex organisms, in particular …

The topographic features of an implant, which mechanically regulate cell behaviors and
functions, are critical for the clinical success in tissue regeneration. How cells sense and …

Quiescence regulation is essential for adult stem cell maintenance and sustained
regeneration. Our studies uncovered that physiological changes in mitochondrial shape …

Cell polarization exists in a variety of tissues to regulate cell behaviors and functions. Space
constraint (spatially limiting cell extension) and adhesion induction (guiding adhesome …

Remarkable exertions are directed to reveal and understand topographic cues that induce
cell mechanical sensitive responses including lineage determination. Extracellular matrix …

Cellular behavior is continuously affected by microenvironmental forces through the process
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …

In cardiovascular tissues, changes in the mechanical properties of the extracellular matrix
are associated with cellular de-differentiation and with subsequent functional declines …

Abstract Changes in the micro-environment of fibrous connective tissue can lead to
alterations in the phenotypes of tissue-resident cells, yet the underlying mechanisms are …