Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

Tumor-derived extracellular vesicles: multifunctional entities in the tumor microenvironment

JW Clancy, C D'Souza-Schorey - Annual Review of Pathology …, 2023 - annualreviews.org
Tumor cells release extracellular vesicles (EVs) that can function as mediators of
intercellular communication in the tumor microenvironment. EVs contain a host of bioactive …

Actin on and around the Nucleus

PM Davidson, B Cadot - Trends in Cell Biology, 2021 - cell.com
Actin plays roles in many important cellular processes, including cell motility, organelle
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …

[HTML][HTML] The ins and outs of microvesicles

JW Clancy, M Schmidtmann… - FASEB …, 2021 - ncbi.nlm.nih.gov
Microvesicles are a heterogeneous group of membrane‐enclosed vesicles that are released
from cells into the extracellular space by the outward budding and pinching of the plasma …

Can't handle the stress? Mechanobiology and disease

N Zuela-Sopilniak, J Lammerding - Trends in molecular medicine, 2022 - cell.com
Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …

An ARF6–Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles

JW Clancy, Y Zhang, C Sheehan… - Nature cell …, 2019 - nature.com
Tumour-derived microvesicles (TMVs) comprise a class of extracellular vesicles released
from tumour cells that are now understood to facilitate communication between the tumour …

Lamin A/C: function in normal and tumor cells

N Dubik, S Mai - Cancers, 2020 - mdpi.com
Simple Summary The aim of this review is to summarize lamin A/C's currently known
functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many …

Super Enhancer–Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis

T Su, N Zhang, T Wang, J Zeng, W Li, L Han, M Yang - Cancer Research, 2023 - AACR
Hepatocellular carcinoma (HCC) is one of the most lethal neoplasms and has a 5-year
survival rate of only 18% in patients with metastatic diseases. Epigenetic modifiers and …

Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis

Y Yan, B Zhou, C Qian, A Vasquez, M Kamra… - Nature …, 2022 - nature.com
Despite progress in prostate cancer (PC) therapeutics, distant metastasis remains a major
cause of morbidity and mortality from PC. Thus, there is growing recognition that preventing …

Extracellular vesicle-associated DNA: ten years since its discovery in human blood

T Tsering, A Nadeau, T Wu, K Dickinson… - Cell Death & …, 2024 - nature.com
Extracellular vesicles (EVs) have emerged as key players in intercellular communication,
facilitating the transfer of crucial cargo between cells. Liquid biopsy, particularly through the …