The pathogenic mechanisms of these diseases must be well understood for the treatment of
neurological disorders such as Huntington's disease. Huntington's Disease (HD), a …

Huntington's disease is an autosomal-dominant, progressive neurodegenerative disorder
with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline …

As a Mendelian neurodegenerative disorder, the genetic risk of Huntington's disease (HD) is
conferred entirely by an HTT CAG repeat expansion whose length is the primary …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase
signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a …

Huntington's disease (HD) is a dominantly inherited progressive neurological disease
characterized by chorea, an involuntary brief movement that tends to flow between body …

The 25 years since the identification of the gene responsible for Huntington disease (HD)
have stood witness to profound discoveries about the nature of the disease and its …

There are currently no effective pharmacological agents available to stop or prevent the
progression of Huntington's disease (HD), a rare hereditary neurodegenerative disorder. In …

Objective: To develop an evidence-based guideline assessing pharmacologic options for
treating Huntington disease (HD) chorea. Methods: We evaluated available evidence from a …

Huntington's disease (HD) is a progressive neurological disease that is inherited in an
autosomal fashion. The cause of disease pathology is an expansion of cytosine-adenine …