Bone mineralization: from tissue to crystal in normal and pathological contexts

Y Bala, D Farlay, G Boivin - Osteoporosis international, 2013 - Springer
Bone is a complex and structured material; its mechanical behavior results from an
interaction between the properties of each level of its structural hierarchy. The degree of …

[HTML][HTML] Post-yield and failure properties of cortical bone

U Wolfram, J Schwiedrzik - BoneKEy reports, 2016 - ncbi.nlm.nih.gov
Ageing and associated skeletal diseases pose a significant challenge for health care
systems worldwide. Age-related fractures have a serious impact on personal, social and …

Effect of the nano crystal size on the X-ray diffraction patterns of biogenic hydroxyapatite from human, bovine, and porcine bones

SM Londoño-Restrepo, R Jeronimo-Cruz… - Scientific reports, 2019 - nature.com
This paper focuses on the study of the effect of the change of the crystal size on the shape
and width of the X-ray diffraction patterns for defatted and deproteinized bones as well as …

Multi-level characterization of human femoral cortices and their underlying osteocyte network reveal trends in quality of young, aged, osteoporotic and antiresorptive …

P Milovanovic, EA Zimmermann, C Riedel… - Biomaterials, 2015 - Elsevier
Abstract Characterization of bone's hierarchical structure in aging, disease and treatment
conditions is imperative to understand the architectural and compositional modifications to …

Biochemical markers of bone turnover in osteoporosis

P Szulc, DC Bauer, R Eastell - Marcus and Feldman's Osteoporosis, 2021 - Elsevier
Bone turnover markers (BTMs) are divided into the markers of bone formation and those of
bone resorption. N-terminal collagen type I extension propeptide and serum C-terminal …

Bone-mineral density: clinical significance, methods of quantification and forensic applications

EF Kranioti, A Bonicelli… - Research and Reports in …, 2019 - Taylor & Francis
Bone-mineral density (BMD) is a measure of the inorganic mineral content in bone, and is
one of the more informative assessments of bone quality in both clinical studies and forensic …

Biomaterial stiffness determines stem cell fate

H Lv, H Wang, Z Zhang, W Yang, W Liu, Y Li, L Li - Life sciences, 2017 - Elsevier
Stem cells have potential to develop into numerous cell types, thus they are good cell source
for tissue engineering. As an external physical signal, material stiffness is capable of …

Compositional and mechanical properties of growing cortical bone tissue: a study of the human fibula

E Lefèvre, D Farlay, Y Bala, F Subtil, U Wolfram… - Scientific reports, 2019 - nature.com
Human cortical bone contains two types of tissue: osteonal and interstitial tissue. Growing
bone is not well-known in terms of its intrinsic material properties. To date, distinctions …

Bone's material constituents and their contribution to bone strength in health, disease, and treatment

Y Bala, E Seeman - Calcified tissue international, 2015 - Springer
Type 1 collagen matrix volume, its degree of completeness of its mineralization, the extent of
collagen crosslinking and water content, and the non-collagenous proteins like osteopontin …

Bone micromechanical properties are compromised during long‐term alendronate therapy independently of mineralization

Y Bala, B Depalle, D Farlay, T Douillard… - Journal of Bone and …, 2012 - academic.oup.com
In the treatment of postmenopausal osteoporosis (PMOP), the use of alendronate (ALN)
leads to a decrease in the risk of vertebral and nonvertebral fractures. To explore the …