G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that
sense signalling molecules such as hormones and neurotransmitters, and are the targets of …

G protein coupled receptors (GPCRs) convey signals across membranes via interaction with
G proteins. Originally, an individual GPCR was thought to signal through one G protein …

The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most
clinically and recreationally used opioids. The induced positive effects of analgesia and …

Muscarinic acetylcholine receptors are G protein–coupled receptors that respond to
acetylcholine and play important signaling roles in the nervous system. There are five …

G-protein-coupled receptor (GPCR)-mediated signal transduction is central to human
physiology and disease intervention, yet the molecular mechanisms responsible for ligand …

G-protein-coupled receptors mediate the biological effects of many hormones and
neurotransmitters and are important pharmacological targets. They transmit their signals to …

G protein–coupled receptors (GPCRs) activate cellular responses ranging from odorants to
neurotransmitters. Binding an agonist leads to activation of a heterotrimeric G protein (GP) …

G-protein–coupled receptors (GPCRs) constitute the largest family of receptors and major
pharmacological targets. Whereas many GPCRs have been shown to form di-/oligomers, the …

Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …