Thioamidation as a posttranslational modification is exceptionally rare, with only a few
reported natural products and exactly one known protein example (methyl-coenzyme M …

Due to advances in methods for site-specific incorporation of unnatural amino acids (UAAs)
into proteins, a large number of UAAs with tailored chemical and/or physical properties have …

Short, synthetic peptides that are displayed by major histocompatibility complex I (MHC I)
can stimulate CD8 T cells in vivo to destroy virus-infected or cancer cells. The development …

Current limitations in de novo protein structure prediction and design suggest an incomplete
understanding of the interactions that govern protein folding. Here we demonstrate that …

Peptide hormones are attractive as injectable therapeutics and imaging agents, but they
often require extensive modification by mutagenesis and/or chemical synthesis to prevent …

Three-Component Reaction between Alkynes, Elemental Sulfur, and Aliphatic Amines: A
General, Straightforward, and Atom Economical Approach to Thioamides | Organic Letters …

It has been established experimentally that aromatic thioketones possess several inherently
unique photophysical properties, some of which are highly sensitive even to common …

Thioamides are single atom substitutions of the peptide bond that serve as versatile probes
of protein structure. Effective use of thioamides requires a robust understanding of the …

We show that substituting a single atom, O to S (amide to thioamide), in a peptide bond
results in global restriction of the conformational flexibility in peptide macrocycles with …

Abundant n→ π* interactions between adjacent backbone carbonyl groups, identified by
statistical analysis of protein structures, are predicted to play an important role in dictating …