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Opportunities and challenges for biosensors and nanoscale analytical tools for pandemics: COVID-19
Biosensors and nanoscale analytical tools have shown huge growth in literature in the past
20 years, with a large number of reports on the topic of 'ultrasensitive','cost-effective', and …
20 years, with a large number of reports on the topic of 'ultrasensitive','cost-effective', and …
Molecular mechanism of HIV-1 entry
B Chen - Trends in microbiology, 2019 - cell.com
HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …
[HTML][HTML] Molecular architecture of the SARS-CoV-2 virus
SARS-CoV-2 is an enveloped virus responsible for the COVID-19 pandemic. Despite recent
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …
nextPYP: a comprehensive and scalable platform for characterizing protein variability in situ using single-particle cryo-electron tomography
Single-particle cryo-electron tomography is an emerging technique capable of determining
the structure of proteins imaged within the native context of cells at molecular resolution …
the structure of proteins imaged within the native context of cells at molecular resolution …
[HTML][HTML] Cryo-electron microscopy for structural analysis of dynamic biological macromolecules
Background Since the introduction of what became today's standard for cryo-embedding of
biological macromolecules at native conditions more than 30 years ago, techniques and …
biological macromolecules at native conditions more than 30 years ago, techniques and …
HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes
Abstract Human immunodeficiency virus 1 (HIV-1) infection is initiated by binding of the viral
envelope glycoprotein (Env) to the cell-surface receptor CD4,,–. Although high-resolution …
envelope glycoprotein (Env) to the cell-surface receptor CD4,,–. Although high-resolution …
Broadly neutralizing antibodies to HIV and their role in vaccine design
HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP. 664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing …
A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-
1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One …
1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One …