Interleukin (IL)-10 is the most important cytokine with anti-inflammatory properties besides
TGF-β and IL-35. It is produced by activated immune cells, in particular monocytes …

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

Inflammation resolution is important for scar formation following myocardial infarction (MI)
and requires the coordinated actions of macrophages and fibroblasts. In this study, we …

Background The molecular cause of inflammatory bowel disease is largely unknown.
Methods We performed genetic-linkage analysis and candidate-gene sequencing on …

Immunity in higher organisms can be broadly categorized into adaptive immunity and innate
immunity. Adaptive immunity is mediated by clonally distributed T and B lymphocytes which …

Tumor-associated macrophages may either promote or suppress tumor growth depending
on their activation status. Interferon-γ (IFN-γ) has been identified as a key factor for inducing …

Interleukin‐10 (IL‐10) has long been recognized to have potent and broad‐spectrum anti‐
inflammatory activity, which has been unequivocally established in various models of …

Toll-like receptors (TLRs) are powerful molecular regulators by which the immune system
may “sense” the environment and protect the host from pathogens or endogenous threats. In …

The cellular mechanisms that directly regulate the inflammatory response after Toll-like
receptor (TLR) stimulation are unresolved at present. Here we report that glycogen synthase …

We have characterized the progressive stages of chronic intestinal inflammation that
develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in …