Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins
Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …
breaks in mammalian cells, the defining step of which is homologous strand exchange …
Repair of strand breaks by homologous recombination
M Jasin, R Rothstein - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast …
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast …
DNA damage and associated DNA repair defects in disease and premature aging
Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2
K Schlacher, H Wu, M Jasin - Cancer cell, 2012 - cell.com
Genes mutated in patients with Fanconi anemia (FA) interact with the DNA repair genes
BRCA1 and BRCA2/FANCD1 to suppress tumorigenesis, but the molecular functions …
BRCA1 and BRCA2/FANCD1 to suppress tumorigenesis, but the molecular functions …
The association between germline BRCA2 variants and sensitivity to platinum‐based chemotherapy among men with metastatic prostate cancer
BACKGROUND Breast cancer 2 (BRCA2)‐associated breast and ovarian cancers are
sensitive to platinum‐based chemotherapy. It is unknown whether BRCA2‐associated …
sensitive to platinum‐based chemotherapy. It is unknown whether BRCA2‐associated …
World Health Organization classification of tumours: Pathology & genetics of tumours of the urinary system and male genital organs
TY Chan - Urology, 2005 - goldjournal.net
This 2004 volume in the World Health Organization series on histologic and genetic ty**
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …
[HTML][HTML] Cancer susceptibility and the functions of BRCA1 and BRCA2
AR Venkitaraman - Cell, 2002 - cell.com
Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
Their ubiquitously expressed protein products are implicated in processes fundamental to all …
Their ubiquitously expressed protein products are implicated in processes fundamental to all …
Regulation of DNA double-strand break repair pathway choice
M Shrivastav, LP De Haro, JA Nickoloff - Cell research, 2008 - nature.com
DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide
variety of genetic alterations including large-or small-scale deletions, loss of heterozygosity …
variety of genetic alterations including large-or small-scale deletions, loss of heterozygosity …
[PDF][PDF] BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies
C Albert, M Haase, A Albert, S Kropf… - Annals of laboratory …, 2020 - synapse.koreamed.org
Background The ability of urinary biomarkers to complement established clinical risk
prediction models for postoperative adverse kidney events is unclear. We assessed the …
prediction models for postoperative adverse kidney events is unclear. We assessed the …
Sensing and repairing DNA double-strand breaks
SP Jackson - Carcinogenesis, 2002 - academic.oup.com
The DNA double-strand break (DSB) is the principle cytotoxic lesion for ionizing radiation
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …