Biodegradable materials, including natural and synthetic polymers and hydrolyzable metals,
constitute the main components of temporary, implantable medical devices. Besides the …

Plaque rupture, usually of a precursor lesion known as a'vulnerable plaque'or'thin-cap
fibroatheroma', is the leading cause of thrombosis. Less-frequent aetiologies of coronary …

Background: Optimal upfront dual antiplatelet therapy (DAPT) duration after complex
percutaneous coronary intervention (PCI) with drug-eluting stents (DES) remains unclear …

Despite the reduction in late thrombotic events with newer-generation drug-eluting stents
(DES), late stent failure remains a concern following stent placement. In-stent …

Implantation of drug-eluting stents (DES) is the dominant treatment strategy for patients with
symptomatic coronary artery disease. However, the first-generation DES had substantial …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Background: Stent thrombosis (ST) is a serious complication following coronary stenting.
Intravascular optical coherence tomography (OCT) may provide insights into mechanistic …

Background—Clinical trials have demonstrated that the second-generation cobalt-chromium
everolimus-eluting stent (CoCr-EES) is superior to the first-generation paclitaxel-eluting …

Objectives: Human coronary bare-metal stents (BMS) and drug-eluting stents (DES) from
autopsy cases with implant duration> 30 days were examined for the presence of neointimal …

Background—The optimal duration of dual antiplatelet therapy (DAPT) after implantation of
drug-eluting coronary stents remains undetermined. We aimed to test whether 6-month …