Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

Since the publication of our previous Perspective dealing with polyamine drug discovery, 1
the field has undergone numerous changes. Most prominent among these changes, from a …

Metabolism of polyamines spermidine and spermine, and their diamine precursor,
putrescine, has been a target for antineoplastic therapy since these naturally occurring alkyl …

Polyamine oxidase (PAO) is a flavin adenine dinucleotide-dependent enzyme involved in
polyamine catabolism. Animal PAOs oxidize spermine (Spm), spermidine (Spd), and/or their …

The recently discovered enzyme lysine-specific demethylase 1 (LSD1) plays an important
role in the epigenetic control of gene expression, and aberrant gene silencing secondary to …

Naturally occurring polyamines (PAs) play a pivotal role in the life of all organisms from
bacteria to man. The human PAs putrescine, spermidine, and spermine are fundamental for …

Spermine and spermidine are natural polyamines that are produced mainly via
decarboxylation of l-ornithine and the sequential transfer of aminopropyl groups from S …

Abstract Hydrogen peroxide (H2O2) is involved in plant defense responses that follow
mechanical damage, such as those that occur during herbivore or insect attacks, as well as …

The post-translational modification of histones plays an important role in chromatin
regulation, a process that insures the fidelity of gene expression and other DNA …

The possible involvement of apoplastic reactive oxygen species produced by the oxidation
of free polyamines in the leaf growth of salinized maize has been studied here. Salt …