The roles of histone deacetylases and their inhibitors in cancer therapy
G Li, Y Tian, WG Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
Dual-target inhibitors based on HDACs: novel antitumor agents for cancer therapy
T Liu, Y Wan, Y ** anti-cancer drugs
Histone deacetylases (HDACs) deacetylate histones H3 and H4. An imbalance between
histone acetylation and deacetylation can lead to various diseases. HDAC2 is present in the …
histone acetylation and deacetylation can lead to various diseases. HDAC2 is present in the …
[HTML][HTML] HDACs and the epigenetic plasticity of cancer cells: Target the complexity
Cancer cells must adapt to the hostile conditions of the microenvironment in terms of
nutrition, space, and immune system attack. Mutations of DNA are the drivers of the …
nutrition, space, and immune system attack. Mutations of DNA are the drivers of the …
How do tumor cells respond to HDAC inhibition?
A Newbold, KJ Falkenberg, HM Prince… - The FEBS …, 2016 - Wiley Online Library
It is now well recognized that mutations, deregulated expression, and aberrant recruitment of
epigenetic readers, writers, and erasers are fundamentally important processes in the onset …
epigenetic readers, writers, and erasers are fundamentally important processes in the onset …