2022 update on prostate cancer epidemiology and risk factors—a systematic review

O Bergengren, KR Pekala, K Matsoukas, J Fainberg… - European urology, 2023 - Elsevier
Abstract Context Prostate cancer (PCa) is one of the most common cancers worldwide.
Understanding the epidemiology and risk factors of the disease is paramount to improve …

Recent advances in polygenic scores: translation, equitability, methods and FAIR tools

R **ang, M Kelemen, Y Xu, LW Harris, H Parkinson… - Genome Medicine, 2024 - Springer
Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic
predisposition to disease, and many potentially clinically useful applications have been …

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A Wang, J Shen, AA Rodriguez, EJ Saunders, F Chen… - Nature …, 2023 - nature.com
The transferability and clinical value of genetic risk scores (GRSs) across populations
remain limited due to an imbalance in genetic studies across ancestrally diverse …

Early prostate cancer deaths among men with higher vs lower genetic risk

A Plym, Y Zhang, KH Stopsack… - JAMA network …, 2024 - jamanetwork.com
Importance Prostate cancer, a leading cause of cancer death among men, urgently requires
new prevention strategies, which may involve targeting men with an underlying genetic …

Evidence of novel susceptibility variants for prostate cancer and a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry

F Chen, RK Madduri, AA Rodriguez, BF Darst, A Chou… - European urology, 2023 - Elsevier
Background Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective To discover common genetic variants contributing to the risk of PCa in men of …

Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects

S Ito, X Liu, Y Ishikawa, DD Conti, N Otomo… - Nature …, 2023 - nature.com
Prostate cancer (PrCa) is the second most common cancer worldwide in males. While
strongly warranted, the prediction of mortality risk due to PrCa, especially before its …

Prostate Cancer Foundation screening guidelines for Black men in the United States

IP Garraway, SV Carlsson, YA Nyame, JL Vassy… - NEJM …, 2024 - evidence.nejm.org
Abstract Background In the United States, Black men are at highest risk for being diagnosed
with and dying from prostate cancer. Given this disparity, we examined relevant data to …

Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa

R Janivara, WC Chen, U Hazra, S Baichoo, I Agalliu… - Nature Genetics, 2024 - nature.com
Men of African descent have the highest prostate cancer incidence and mortality rates, yet
the genetic basis of prostate cancer in African men has been understudied. We used …

Polygenic scores in the direct-to-consumer setting: challenges and opportunities for a new era in consumer genetic testing

JK Park, CY Lu - Journal of Personalized Medicine, 2023 - mdpi.com
Direct-to-consumer (DTC) genetic tests have generated considerable scholarly attention and
public intrigue. Although the current consumer genetic testing regime relies on the reporting …

Global viewpoints: updates on prostate cancer in Sub‐Saharan Africa

M Jalloh, A Cassell, L Niang, T Rebbeck - BJU international, 2024 - Wiley Online Library
Prostate cancer (PCa) is a major health concern in Sub‐Saharan Africa (SSA), with high
incidence and mortality rates. However, the widely used prostate‐specific antigen (PSA) …