The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the
dynamics of early cellular responses to this disease remains limited. Here in our SARS-CoV …

The central nervous system is the most important nervous system in vertebrates, which is
responsible for transmitting information to the peripheral nervous system and controlling the …

Somatic mutations together with immunoediting drive extensive heterogeneity within non-
small-cell lung cancer (NSCLC). Herein we examine heterogeneity of the T cell antigen …

Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of
protective immunity to future variants, but we lack insights into immune responses before or …

The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an
important determinant of adaptive immunity. We estimated the abundance of TCR …

TCR-gene-transfer is an efficient strategy to produce therapeutic T cells of defined antigen
specificity. However, there are substantial variations in the cell surface expression levels of …

The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the
cellular disease dynamics remains limited. In our unique COVID-19 human challenge study …

T cell responses precede antibody and may provide early control of infection. We analyzed
the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell …

The T cell receptor repertoire provides a window into the cellular adaptive immune
response. In the context of cancer, determining the repertoire within a tumor can give …

Diphenylcyclopropenone (DPC) is an organic chemical hapten which induces allergic
contact dermatitis and is used in the treatment of warts, melanoma, and alopecia areata …