Gut microbiota and hypertension: association, mechanisms and treatment

Z Yang, Q Wang, Y Liu, L Wang, Z Ge, Z Li… - Clinical and …, 2023‏ - Taylor & Francis
Objectives Hypertension is one of the most important risk factors for cardio-cerebral vascular
diseases, which brings a heavy economic burden to society and becomes a major public …

[HTML][HTML] Biological effects of indole-3-propionic acid, a gut microbiota-derived metabolite, and its precursor tryptophan in mammals' health and disease

P Konopelski, I Mogilnicka - International journal of molecular sciences, 2022‏ - mdpi.com
Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020‏ - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease

N Paeslack, M Mimmler, S Becker, Z Gao, MP Khuu… - Amino Acids, 2022‏ - Springer
The essential amino acid tryptophan (Trp) is metabolized by gut commensals, yielding in
compounds that affect innate immune cell functions directly, but also acting on the aryl …

The reactive species interactome: evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine

MM Cortese-Krott, A Koning, GGC Kuhnle… - Antioxidants & redox …, 2017‏ - liebertpub.com
Significance: Oxidative stress is thought to account for aberrant redox homeostasis and
contribute to aging and disease. However, more often than not, administration of …

[HTML][HTML] The gut microbial metabolite trimethylamine N-oxide and hypertension risk: a systematic review and dose–response meta-analysis

X Ge, L Zheng, R Zhuang, P Yu, Z Xu, G Liu, X **… - Advances in …, 2020‏ - Elsevier
The gut microbial metabolite trimethylamine N-oxide (TMAO) is increasingly regarded as a
novel risk factor for cardiovascular events and mortality. However, little is known about the …

[HTML][HTML] Desulfovibrio bacteria are associated with Parkinson's disease

KE Murros, VA Huynh, TM Takala… - Frontiers in Cellular and …, 2021‏ - frontiersin.org
Parkinson's disease (PD) is the most prevalent movement disorder known and
predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α …

Early-onset preeclampsia is associated with gut microbial alterations in antepartum and postpartum women

LJ Lv, SH Li, SC Li, ZC Zhong, HL Duan… - Frontiers in cellular …, 2019‏ - frontiersin.org
Background: Imbalances in gut microbiota composition are linked to hypertension, host
metabolic abnormalities, systemic inflammation, and other conditions. In the present study …

Gut bacteria and hydrogen sulfide: the new old players in circulatory system homeostasis

L Tomasova, P Konopelski, M Ufnal - Molecules, 2016‏ - mdpi.com
Accumulating evidence suggests that gut bacteria play a role in homeostasis of the
circulatory system in mammals. First, gut bacteria may affect the nervous control of the …

[HTML][HTML] Hydrogen sulfide in pharmacotherapy, beyond the hydrogen sulfide-donors

E Zaorska, L Tomasova, D Koszelewski, R Ostaszewski… - Biomolecules, 2020‏ - mdpi.com
Hydrogen sulfide (H2S) is one of the important biological mediators involved in
physiological and pathological processes in mammals. Recently developed H2S donors …