Free radical damage in ischemia‐reperfusion injury: an obstacle in acute ischemic stroke after revascularization therapy

MS Sun, H **, X Sun, S Huang… - Oxidative medicine …, 2018‏ - Wiley Online Library
Acute ischemic stroke is a common cause of morbidity and mortality worldwide.
Thrombolysis with recombinant tissue plasminogen activator and endovascular …

[HTML][HTML] Happily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

A Höhn, D Weber, T Jung, C Ott, M Hugo, B Kochlik… - Redox biology, 2017‏ - Elsevier
Aging is a complex phenomenon and its impact is becoming more relevant due to the rising
life expectancy and because aging itself is the basis for the development of age-related …

Excitotoxicity: still hammering the ischemic brain in 2020

DW Choi - Frontiers in neuroscience, 2020‏ - frontiersin.org
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …

The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder

PK Maurya, C Noto, LB Rizzo, AC Rios… - Progress in Neuro …, 2016‏ - Elsevier
Major depressive disorder (MDD) affects millions of individuals and is highly comorbid with
many age-associated diseases such as diabetes mellitus, immune-inflammatory …

Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration

Y Li, L Andereggen, K Yuki, K Omura, Y Yin… - Proceedings of the …, 2017‏ - pnas.org
Retinal ganglion cells (RGCs), the projection neurons of the eye, cannot regenerate their
axons once the optic nerve has been injured and soon begin to die. Whereas RGC death …

ROS and intracellular ion channels

K Kiselyov, S Muallem - Cell Calcium, 2016‏ - Elsevier
Oxidative stress is a well-known driver of numerous pathological processes involving protein
and lipid peroxidation and DNA damage. The resulting increase of pro-apoptotic pressure …

How cellular Zn2+ signaling drives physiological functions

N Levaot, M Hershfinkel - Cell Calcium, 2018‏ - Elsevier
Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …

Alzheimer's disease: as it was in the beginning

S Kozlov, A Afonin, I Evsyukov… - Reviews in the …, 2017‏ - degruyter.com
Since Alzheimer's disease was first described in 1907, many attempts have been made to
reveal its main cause. Nowadays, two forms of the disease are known, and while the …

Synaptic zinc: an emerging player in Parkinson's disease

J Sikora, AM Ouagazzal - International journal of molecular sciences, 2021‏ - mdpi.com
Alterations of zinc homeostasis have long been implicated in Parkinson's disease (PD). Zinc
plays a complex role as both deficiency and excess of intracellular zinc levels have been …

A Neurotoxic Ménage-à-trois: Glutamate, Calcium, and Zinc in the Excitotoxic Cascade

A Granzotto, LMT Canzoniero, SL Sensi - Frontiers in molecular …, 2020‏ - frontiersin.org
Fifty years ago, the seminal work by John Olney provided the first evidence of the neurotoxic
properties of the excitatory neurotransmitter glutamate. A process hereafter termed …