Many invertebrates and ectothermic vertebrates successfully cope with a fluctuating supply
of ambient oxygen—and consequently, a highly variable tissue oxygenation—through …

The naked mole-rat (NMR) is a subterranean rodent that has gained significant attention
from the biomedical research community in recent years as molecular mechanisms …

Goldfish enter a hypometabolic state to survive chronic hypoxia. We recently described
tissue-specific contributions of membrane lipid composition remodeling and mitochondrial …

Without oxygen, most vertebrates die within minutes as they cannot meet cellular energy
demands with anaerobic metabolism. However, fish of the genus Carassius (crucian carp …

The crucian carp is probably the most anoxia-tolerant fish there is, surviving without oxygen
for days to months depending on temperature. The anoxia tolerance has evolved in …

Decreased oxygen availability impairs cellular energy production and, without a coordinated
and matched decrease in energy consumption, cellular and whole organism death rapidly …

Just over two decades ago, Bob Boutilier published a much-cited Review in this journal on
the mechanisms of cell survival in hypoxia and hypothermia. Here, we celebrate this …

Nitrite (NO2−) functions as an important nitric oxide (NO) donor under hypoxic conditions.
Both nitrite and NO have been found to protect the mammalian heart and other tissues …

How do vertebrates get the oxygen they need, or even manage without it for shorter or
longer periods of time? How do they sense oxygen, how do they take it up from water or air …

The crucian carp (Carassius carassius) tolerates anoxia for days to months depending on
temperature. During episodes of stress, heat shock proteins (HSPs) are important for limiting …