BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …

Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and
environmental factors, poses a significant risk for the development of coronary artery …

Preeclampsia (PE) is a hypertensive pregnancy disorder with increased risk of maternal and
fetal morbidity and mortality. Abnormal extravillous trophoblast (EVT) development and …

Background Human placental DNA methylation (DNAme) data is a valuable resource for
studying sex differences during gestation, as DNAme profiles after delivery reflect the …

Genetic and prenatal environmental factors shape fetal development and cardiometabolic
health in later life. A key target of genetic and prenatal environmental factors is the …

The placenta is crucial for fetal development, is affected by PFAS toxicity, and evidence is
accumulating that gestational PFAS perturb the epigenetic activity of the placenta …

Hypertensive disorders of pregnancy (HDP) contribute substantially to perinatal morbidity
and mortality. Epigenetic changes point towards cardio-metabolic dysregulation for these …

STUDY QUESTION Do differences in blood pressure within the normal range have any
impacts on the live birth rate (primary outcome) or biochemical pregnancy rate (beta-hCG …

Orofacial clefts (OFCs) are one of the most common types of structural birth defects. The
etiologies are complicated, involving with genetic, epigenetic, and environmental factors …

Preeclampsia (PE) is a dangerous hypertensive disorder that occurs during pregnancy. The
specific aetiology and pathogenesis of PE have yet to be clarified. To better reveal the …