Molecular markers for malaria genetic epidemiology: progress and pitfalls

S Ruybal-Pesántez, K McCann, J Vibin, S Siegel… - Trends in …, 2024 - cell.com
Over recent years, progress in molecular markers for genoty** malaria parasites has
enabled informative studies of epidemiology and transmission dynamics. Results have …

PfEMP1 and var genes-Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity

L Hviid, AR Jensen, KW Deitsch - Advances in …, 2024 - pubmed.ncbi.nlm.nih.gov
The most severe form of malaria, caused by infection with Plasmodium falciparum parasites,
continues to be an important cause of human suffering and poverty. The P. falciparum …

Comparison of molecular surveillance methods to assess changes in the population genetics of Plasmodium falciparum in high transmission

A Ghansah, KE Tiedje, DC Argyropoulos… - Frontiers in …, 2023 - frontiersin.org
A major motivation for develo** molecular methods for malaria surveillance is to measure
the impact of control interventions on the population genetics of Plasmodium falciparum as a …

A paradoxical population structure of var DBLα types in Africa

MH Tan, KE Tiedje, Q Feng, Q Zhan, M Pascual… - PLoS …, 2025 - journals.plos.org
The var multigene family encodes Plasmodium falciparum erythrocyte membrane protein 1
(PfEMP1), central to host-parasite interactions. Genome structure studies have identified …

Comparative analysis of targeted next-generation sequencing for Plasmodium falciparum drug resistance markers

C Kunasol, AM Dondorp, EM Batty, V Nakhonsri… - Scientific Reports, 2022 - nature.com
Well-defined molecular resistance markers are available for a range of antimalarial drugs,
and molecular surveillance is increasingly important for monitoring antimalarial drug …

Unravelling var complexity: Relationship between DBLα types and var genes in Plasmodium falciparum

MH Tan, H Shim, Y Chan, KP Day - Frontiers in parasitology, 2023 - frontiersin.org
The enormous diversity and complexity of var genes that diversify rapidly by recombination
has led to the exclusion of assembly of these genes from major genome initiatives (eg, Pf6) …

Molecular epidemiology of continued Plasmodium falciparum disease transmission after an outbreak in Ecuador

S Ruybal-Pesántez, FE Sáenz, SL Deed… - Frontiers in tropical …, 2023 - frontiersin.org
To better understand the factors underlying the continued incidence of clinical episodes of
falciparum malaria in E-2025 countries targeting elimination, we characterized the molecular …

Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance

Q He, JK Chaillet, F Labbé - Elife, 2024 - elifesciences.org
The establishment and spread of antimalarial drug resistance vary drastically across
different biogeographic regions. Though most infections occur in sub-Saharan Africa …