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Molecular markers for malaria genetic epidemiology: progress and pitfalls
Over recent years, progress in molecular markers for genoty** malaria parasites has
enabled informative studies of epidemiology and transmission dynamics. Results have …
enabled informative studies of epidemiology and transmission dynamics. Results have …
PfEMP1 and var genes-Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity
L Hviid, AR Jensen, KW Deitsch - Advances in …, 2024 - pubmed.ncbi.nlm.nih.gov
The most severe form of malaria, caused by infection with Plasmodium falciparum parasites,
continues to be an important cause of human suffering and poverty. The P. falciparum …
continues to be an important cause of human suffering and poverty. The P. falciparum …
Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents
Malaria remains a major public health problem in many countries. Unlike influenza and HIV,
where diversity in immunodominant surface antigens is understood geographically to inform …
where diversity in immunodominant surface antigens is understood geographically to inform …
Comparison of molecular surveillance methods to assess changes in the population genetics of Plasmodium falciparum in high transmission
A major motivation for develo** molecular methods for malaria surveillance is to measure
the impact of control interventions on the population genetics of Plasmodium falciparum as a …
the impact of control interventions on the population genetics of Plasmodium falciparum as a …
A paradoxical population structure of var DBLα types in Africa
The var multigene family encodes Plasmodium falciparum erythrocyte membrane protein 1
(PfEMP1), central to host-parasite interactions. Genome structure studies have identified …
(PfEMP1), central to host-parasite interactions. Genome structure studies have identified …
Comparative analysis of targeted next-generation sequencing for Plasmodium falciparum drug resistance markers
Well-defined molecular resistance markers are available for a range of antimalarial drugs,
and molecular surveillance is increasingly important for monitoring antimalarial drug …
and molecular surveillance is increasingly important for monitoring antimalarial drug …
Unravelling var complexity: Relationship between DBLα types and var genes in Plasmodium falciparum
The enormous diversity and complexity of var genes that diversify rapidly by recombination
has led to the exclusion of assembly of these genes from major genome initiatives (eg, Pf6) …
has led to the exclusion of assembly of these genes from major genome initiatives (eg, Pf6) …
Molecular epidemiology of continued Plasmodium falciparum disease transmission after an outbreak in Ecuador
To better understand the factors underlying the continued incidence of clinical episodes of
falciparum malaria in E-2025 countries targeting elimination, we characterized the molecular …
falciparum malaria in E-2025 countries targeting elimination, we characterized the molecular …
Clinical malaria incidence following an outbreak in Ecuador was predominantly associated with Plasmodium falciparum with recombinant variant antigen gene …
To better understand the factors underlying the continued incidence of clinical episodes of
falciparum malaria in E-2020 countries targeting elimination, we have characterised …
falciparum malaria in E-2020 countries targeting elimination, we have characterised …
Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance
The establishment and spread of antimalarial drug resistance vary drastically across
different biogeographic regions. Though most infections occur in sub-Saharan Africa …
different biogeographic regions. Though most infections occur in sub-Saharan Africa …