Organ-on-a-chip: Recent breakthroughs and future prospects

Q Wu, J Liu, X Wang, L Feng, J Wu, X Zhu… - Biomedical engineering …, 2020 - Springer
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …

Tumor-on-a-chip: from bioinspired design to biomedical application

X Liu, J Fang, S Huang, X Wu, X **e, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

Advances in functional polymer nanofibers: From spinning fabrication techniques to recent biomedical applications

DM Dos Santos, DS Correa, ES Medeiros… - … applied materials & …, 2020 - ACS Publications
Functional polymeric micro-/nanofibers have emerged as promising materials for the
construction of structures potentially useful in biomedical fields. Among all kinds of …

Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

Microfluidic organ-on-a-chip: a guide to biomaterial choice and fabrication

UMN Cao, Y Zhang, J Chen, D Sayson, S Pillai… - International journal of …, 2023 - mdpi.com
Organ-on-A-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to
recapitulate the in vivo physiology of an organ using different cell types and extracellular …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Nanofibers for biomedical and healthcare applications

R Rasouli, A Barhoum, M Bechelany… - Macromolecular …, 2019 - Wiley Online Library
Unique features of nanofibers provide enormous potential in the field of biomedical and
healthcare applications. Many studies have proven the extreme potential of nanofibers in …

Biodegradable polymers as the pivotal player in the design of tissue engineering scaffolds

F Zhang, MW King - Advanced healthcare materials, 2020 - Wiley Online Library
Biodegradable polymers play a pivotal role in in situ tissue engineering. Utilizing various
technologies, researchers have been able to fabricate 3D tissue engineering scaffolds using …

Organ‐on‐chip models: implications in drug discovery and clinical applications

R Mittal, FW Woo, CS Castro, MA Cohen… - Journal of cellular …, 2019 - Wiley Online Library
Before a lead compound goes through a clinical trial, preclinical studies utilize two‐
dimensional (2D) in vitro models and animal models to study the pharmacodynamics and …

Lung-on-a-chip: the future of respiratory disease models and pharmacological studies

J Shrestha, S Razavi Bazaz… - Critical reviews in …, 2020 - Taylor & Francis
Abstract Recently, organ-on-a-chip models, which are microfluidic devices that mimic the
cellular architecture and physiological environment of an organ, have been developed and …