Interrogating biological systems is often limited by access to biological probes. The
emergence of “click chemistry” has revolutionized bioconjugate chemistry by providing facile …

Microarrays are powerful tools in biomedical research and have become indispensable for
high-throughput multiplex analysis, especially for DNA and protein analysis. The basis for all …

Small extracellular vesicles (sEVs) present fairly distinctive lipid membrane features in the
extracellular environment. These include high curvature, lipid-packing defects and a relative …

A workflow for rapid SARS-CoV-2 epitope discovery on peptide microarrays is herein
reported. The process started with a proteome-wide screening of immunoreactivity based on …

SARS-CoV-2 is a health threat with dire socioeconomical consequences. As the crucial
mediator of infection, the viral glycosylated spike protein (S) has attracted the most attention …

The SARS-CoV-2 spike (S) protein is exposed on the viral surface and is the first point of
contact between the virus and the host. For these reasons it represents the prime target for …

Introduction: One main limitation in biomarker studies using EVs is the lack of a suitable
isolation method rendering high yield and purity samples in a quick and easily standardized …

The mosquito-borne viral disease caused by the Dengue virus is an expanding global
threat. Diagnosis in low-resource-settings and epidemiological surveillance urgently …

Canonical immunoassays rely on highly sensitive and specific capturing of circulating
biomarkers by interacting biomolecular baits. In this frame, bioprobe immobilization in …

As an effective strategy to develop novel implants with a biomolecule, the efficiency of a
copper-catalysed azide-alkyne cycloaddition (CuAAC) urgently requires improvement …